PD-OPA1-A495V#72

General

Cell Line

hPSCreg name OSRi001-A
Cite as:
OSRi001-A (RRID:CVCL_WN91)
Alternative name(s)
PD-OPA1-A495V#72
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
LCSBi012-A-1
(RHOT1_T610A_clone62.19.37_IsogenicControl)
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Parkinson Disease
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Parkinson Disease
SUSMi005-A-1
(SNCA3X 0KO C1, SNCA3X 0KO C2)
Donor diseases:
obsolete_Parkinson's disease
SUSMi005-A-2
(SNCA3X 1KO C2, SNCA3X 1KO C1)
Donor diseases:
obsolete_Parkinson's disease
SUSMi005-A-3
(SNCA3X 2KO C1, SNCA3X 2KO C2)
Donor diseases:
obsolete_Parkinson's disease
SUSMi005-A-4
(SNCA3X 3KO C1, SNCA3X 3KO C2)
Donor diseases:
obsolete_Parkinson's disease
SUSMi005-A-5
(SNCA3X 4KO C1, SNCA3X 4KO C2)
Donor diseases:
obsolete_Parkinson's disease
LCSBi011-A-1
(RHOT1_T351A_clone25.2_IsogenicControl)
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Parkinson Disease
LCSBi001-A
(VPS35 1_2)
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obsolete_Parkinson's disease
LCSBi013-A
(GL2)
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Parkinson Disease
EDi001-A-1
(AST22-C, AST23-C)
Donor's gene variants:
SNCA, SNCA
Donor diseases:
Parkinson disease
EDi001-A-2
(AST23-1KO-3, AST22-1KO-3, AST-23_SCAKO Clone 3, AST-22_SNCAKO Clone 3)
Donor's gene variants:
SNCA, SNCA, SNCA, SNCA
Donor diseases:
Parkinson disease
EDi001-A-3
(AST23_SNCAKO Clone 1, AST22-1KO-1, AST23-1KO-1, AST22_SNCAKO Clone 1)
Donor's gene variants:
SNCA, SNCA, SNCA, SNCA
Donor diseases:
Parkinson disease
EDi001-A-4
(AST22-2KO-6, AST23_SNCAKO Clone 6, AST22_SNCAKO Clone 6, AST23-2KO-6)
Donor's gene variants:
SNCA, SNCA, SNCA, SNCA
Donor diseases:
Parkinson disease
MPIi003-A-1
(IM2GC, L2-2GC)
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obsolete_Parkinson's disease
EDi001-B-1
(AST18-7A)
Donor's gene variants:
SNCA
Donor diseases:
Parkinson disease
EDi001-B-2
(AST18-7B)
Donor's gene variants:
SNCA
Donor diseases:
Parkinson disease
EDi001-B-3
(AST18-5D)
Donor's gene variants:
SNCA
Donor diseases:
Parkinson disease
EDi001-B-4
(AST18-6A)
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SNCA
Donor diseases:
Parkinson disease
EDi001-A-5
(AST23-2KO-II8B)
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SNCA
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Parkinson disease
LCPHi003-A
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LRP10
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Parkinson Disease
UMi036-A
(ND34263)
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Parkinson Disease
ZZUi027-A
(ZZU-iPS-PD-RAB39b-002)
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Parkinson Disease
FDHSi002-A
(FDITBRi002-A)
Donor diseases:
Parkinson Disease
STBCi004-B-1
(SFC832-03-06 LRRK2WT/WT C47)
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LRRK2
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Parkinson disease
STBCi320-A
(SFC031-03-03)
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Parkinson disease
STBCi295-B
(SFC847-03-08)
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Parkinson disease
DANi002-C
(GBA-002-C3)
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GBA
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Parkinson Disease
DANi003-H
(GBA-003-C8)
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GBA
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Parkinson Disease
DANi005-A
(LRRK2-GBA-005-C1)
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GBA, LRRK2
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Parkinson Disease
DANi007-A
(PINK1-007-C1)
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PINK1
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Parkinson Disease
DANi008-F
(SNCA-008-C6)
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SNCA
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LCSBi009-A-1
(RHOT1_R272Q_clone18_IsogenicControl)
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LCSBi010-A-1
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Parkinson Disease
LCSBi010-A-2
(RHOT1_R450C_clone10_IsogenicControl)
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Parkinson Disease
ICGi034-A-1
(PD30-XBP-RFP-6, PD30-4-7-XBP-RFP-6)
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obsolete_Parkinson's disease
DANi011-A
(LRRK2-011-C1)
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LRRK2
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Parkinson Disease
LCSBi009-A
(RHOT1_R272Q_clone1_PD)
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Parkinson Disease
ICGi034-A-2
(PD30-4-7-XBP-RFP-51, PD30-XBP-RFP-51)
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obsolete_Parkinson's disease
LCSBi010-A
(RHOT1_R450C_clone5_PD)
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Parkinson Disease
LCPHi001-A
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GBA
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obsolete_Parkinson's disease
GIBHi003-A
(PINK1-I368N-C2)
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PINK1
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Parkinson Disease
ICGi015-B-1
(m6.7pCyto-17)
Donor diseases:
Parkinson Disease
ICGi015-B-2
(m6.7pCyto-21)
Donor diseases:
Parkinson Disease
ICGi015-B-3
(m6.7pCyto-24)
Donor diseases:
Parkinson Disease
DANi004-A
(PRKN-004-C1)
Donor's gene variants:
PRKN
Donor diseases:
Parkinson Disease
DANi006-F
(GBA-006-C6)
Donor's gene variants:
GBA
Donor diseases:
Parkinson Disease
DANi010-A
(GBA-010-C1)
Donor's gene variants:
GBA
Donor diseases:
Parkinson Disease
Last update 22nd May 2019
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Provider

Generator Ospedale San Raffaele (OSR)

External Databases

BioSamples SAMEA5712221
Cellosaurus CVCL_WN91
Wikidata Q98128383

General Information

* Is the cell line readily obtainable for third parties?
No

Donor Information

General Donor Information

Sex male
Ethnicity Caucasian

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
The donor is affected.
Stage
Late stage
Synonyms
  • Parkinson Disease
  • Parkinson's disease
  • Parkinson's Disease

External Databases (Donor)

BioSamples SAMEA5712222

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? No
Please provide contact information of the holder of the original Donor Information Sheet. Prof. Valerio Carelli, IRCCS Institute of Neurological Sciences of Bologna (ISNB), Bellaria Hospital, Bologna
Do you (Depositor/Provider) hold the original Donor Consent Form? No
If you do not hold the Donor Consent Form, do you know who does? Yes
Please provide the contact information Prof. Valerio Carelli, IRCCS Institute of Neurological Sciences of Bologna (ISNB), Bellaria Hospital, Bologna
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. pseudonymised
Does consent explicitly allow the derivation of pluripotent stem cells? No
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed? Controlled Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? Comitato Etico dell'Azienda Ospedaliera-Universitaria di Bologna
Approval number Prot. 123/2006
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the PROPOSED PROJECT, involving use of donated embryo/tissue or derived cells? Yes
Name of accrediting authority involved? Comitato Etico dell'Azienda Ospedaliera-Universitaria di Bologna
Approval number Prot. 123/2006
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

Source cell type
Source cell origin
Synonyms
  • Arm muscle

Reprogramming method

Vector type Non-integrating
Vector Sendai virus
Genes

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium mTeSR™ 2

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
NANOG
Yes
POU5F1 (OCT-4)
Yes
SOX2
Yes
TRA 1-60
Yes
Differentiation Potency
Endoderm
Ont Id: UBERON_0000925
In vitro directed differentiation
Smooth Muscle Cell
Ont Id: CL_0000192
In vitro spontaneous differentiation
Neuroepithelial Stem Cell
Ont Id: CL_0002259
In vitro directed differentiation

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
46XY
Passage number: 21
Karyotyping method: G-Banding

Other Genotyping (Cell Line)