General

Cell Line

hPSCreg name BIHi005-A-5
Cite as:
BIHi005-A-5 (RRID:CVCL_UW20)
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
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(SCVI-112)
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(ApoE 2/2)
Donor's gene variants:
APOE, APOE
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Alzheimer disease
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(ApoE 3/3)
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APOE, APOE
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Alzheimer disease
UKBi011-A-4
(ApoE 3/4)
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APOE, APOE
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UKBi011-A-1
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STBCi006-A-3
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APOE, APOE
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Alzheimer disease
STBCi006-A-4
(ApoE 3/4)
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APOE, APOE
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UMi042-A-1
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STBCi006-A-1
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APOE, APOE
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BIONi010-C-2
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BIONi010-C-3
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BIONi010-C-25
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BIONi010-C-7
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BIONi010-C-8
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BIONi010-C-9
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BIONi010-C-17
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BIONi010-C-70
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BIONi010-C-71
(BIONi010-C with an APOE 3/3 genotype with an additional, homozygous christchurch mutation)
BIONi010-C-4
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BIONi010-C-5
(BIONi010-C CD33 E2del #N14 P26)
UCSFi001-A-74
(FUS-P525L HET 2D1)
UCSFi001-A-75
(FUS-P525L HOM 2D2)
CBIGi001-A-1
(PRKN-KO, PRKN-KO/AIW002-02)
WAe001-A-76
(H1-RNF1-/-)
CBIGi001-A-2
(PINK1-KO, PINK1-KO/AIW002-02)
CBIGi001-A-3
(PINK1-KO/PRKN-KO/AIW002-02, PINK1-KO/PRKN-KO)
UQi001-A-1
(C11-TDP43-A382T)
UCSFi001-A-72
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UCSFi001-A-73
(FUS-R521G HOM 1D9)
Last update 22nd May 2019
Notes SORL1 KO in BIHi005-A
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Provider

Generator Berlin Institute of Health (BIH)
Derivation country Germany

External Databases

BioSamples SAMEA1009819
Cellosaurus CVCL_UW20
Wikidata Q93426476

General Information

* Is the cell line readily obtainable for third parties?
Yes
Research use: allowed
Clinical use: not allowed
Commercial use: not allowed
Subclone of

Donor Information

General Donor Information

Sex male
Ethnicity asian

Phenotype and Disease related information (Donor)

Diseases No disease was diagnosed.
Family history Mutation in the LMNA gene in other family members but not in this sample frame shift mutation in the LMNA gene that leads to the early termination of translation (c. 349_350insG; p. K117fs)

Other Genotyping (Donor)

Is there genome-wide genotyping or functional data available?
No

Donor Relations

Other cell lines of this donor
All cell lines of this donor's relatives

External Databases (Donor)

BioSamples SAMEA104012190

Ethics

Also have a look at the ethics information for the parental line BIHi005-A .
Alternatives to consent
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

The source cell information can be found in the parental cell line BIHi005-A.

Reprogramming method

Vector type Non-integrating
Vector Sendai virus
Is reprogramming vector detectable?
No
Methods used
Immunostaining

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium Essential 8™

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
NANOG
Yes
POU5F1 (OCT-4)
Yes
SSEA-4
Yes
SOX2
Yes
Differentiation Potency

Genotyping

Karyotyping (Cell Line)

Other Genotyping (Cell Line)

Genetic Modification

Disease/phenotype related modifications
Synonyms
  • Disease, Alzheimer
  • Dementia in Alzheimer's disease, unspecified (disorder)
  • Presenile Alzheimer Dementia
  • ALZHEIMERS DIS
  • Alzheimers
  • DAT - Dementia Alzheimer's type
  • Dementia in Alzheimer's disease
  • Alzheimer's disease, NOS
  • Alzheimer Dementia, Presenile
  • Dementia, Alzheimer Type
  • Alzheimer's
  • Dementia, Presenile
  • [X]Dementia in Alzheimer's disease (disorder)
  • ALZHEIMER DIS
  • AD
  • [X]Dementia in Alzheimer's disease
  • AD - Alzheimer's disease
  • Disease, Alzheimer's
  • Dementia, Presenile Alzheimer
  • Alzheimer Type Dementia
  • Dementia in Alzheimer's disease (disorder)
  • Alzheimer's disease (disorder)
  • Dementia of the Alzheimer's type
  • sporadic Alzheimer's disease
  • Alzheimers disease
  • Alzheimer Dementia
  • Alzheimer's Dementia
  • Alzheimer Disease
  • Alzheimers Dementia
show more synonyms
Genetic modifications
SORL1 (target)
Gene knock-out
11q24.1
TALEN