Italy

Legal status	VERY RESTRICTIVE
Key organization	Ministry of Health (Italian) National Bioethics Committee
Policy	hESC research is prohibited unless it is specifically aimed at improving the therapeutic and medical condition of the embryo concerned. Derivation of embryonic stem cell lines is prohibited. Embryonic cell import is allowed for research.
Legislation	Regulation of Medically Assisted Reproduction, Law No. 40, Article 13 (2004)
Legislation Link	http://www.ieb-eib.org/nl/pdf/loi-pma-italie-english.pdf
Embryonic stem cell research policy	The opinion of a local ethics committee is required prior to the import of hES cell lines.
Research with embryo	Any experimentation on human embryos is expressly prohibits by Law 40/2004.
Somatic cell nuclear transfer	Forbidden.
Genetic modification or selection	Forbidden.
Privacy and data protection	Italian Personal Data Protection Code, Legislative Decree No. 196 of June 30, 2003: http://www.garanteprivacy.it/gar ante/doc.jsp?ID=1030925

Projects

• A functional dissection of the genetic circuits selected in Anatomically Modern Humans and inferred from the study of neurodevelopmental disorders
• Designer extracellular matrices to program healthy and diseased cardiac morphogenesis
• Dissecting the crosstalk between metabolism and transcriptional regulation in pluripotent stem cells.
• Dissecting the molecular regulation of hematopoietic stem cell emergence using pluripotent stem cells to improve ex vivo therapies
• Dissecting the regulatory logic of cell fate reprogramming through integrative and single cell genomics
• EGFR signalling talks to mitochondria through contact sites
• Engineering the Origin of Human Shape: Defining Patterns and Axes in the Early Stage of 3D Pluripotency
• Evolving Organs-on-Chip from developmental engineering to “mechanical re-evolution”
• HD-DittoGraph: a digital human Embryonic Stem Cell platform for Huntington’s repeats
• Illuminating radial genome organization in the nucleus
• Mesh electrode arrays for organoid integration
• Novel Strategies for Cell-based Neural Reconstruction
• Patient-derived disease modeling as a tool to uncover the molecular pathogenesis of neurodevelopmental disorders (NDDs)
• Reprogramming of somatic cells into organOids: patient-centred neurodevelopmental disease modelling from nascent induced pluripotency
• reproids
• Sequence-structure-function: uncovering how genetic variation at human centromere drives cellular phenotypes
• Unraveling huntingtin function in cortical and striatal human development

Provider

• Centro Cardiologico Monzino IRCCS
• EURAC Research Institute for Biomedicine
• European Institute of Oncology IRCCS
• Fondazione Casa Sollievo della Sofferenza IRCCS
• Fondazione Human Technopole
• Fondazione IRCCS Istituto Neurologico C. Besta
• Human Technopole
• International Centre for Genetic Engineering and Biotechnology
• IRCCS - Istituto di Ricerche Farmacologiche Mario Negri
• IRCCS Fondazione Stella Maris
• IRCCS Istituto Clinico Humanitas
• IRCCS Istituto Giannina Gaslini
• IRCCS Policlinico San Matteo
• IRCSS Giannina Gaslini Institute
• IRCSS Giannina Gaslini Institute
• Istituto Auxologico Italiano IRCCS
• Istituto di Ricerche Farmacologiche Mario Negri IRCCS
• Italian Institute of Technology
• Meyer Children's Hospital IRCCS
• Meyer Children's Hospital IRCCS
• Niccolò Cusano University Foundation
• Niccolo Cusano University Foundation
• Ospedale San Raffaele
• Ospedale San Raffaele - San Raffaele Telethon Institute for Gene Therapy (SR-Tiget)
• Sapienza University of Rome
• Telethon Institute of Genetics and Medicine
• Units of Biology and Genetics - University of Pavia
• Università Cattolica del Sacro Cuore- Fondazione Policlinico Universitario "A. Gemelli" IRCCS
• Università degli Studi di Trento
• Università degli Studi Magna Graecia di Catanzaro
• University of Brescia
• University of Ferrara
• University of Milan
• University of Naples Federico II
• University of Padova
• University of Trieste

hESC Cell lines

• WAe009-A-37

hiPSC Cell lines

• IRFMNi001-A
• PSMi001-A
• UNIPDi001-A
• UNIBSi001-A
• UNIBSi002-A
• UNIBSi003-A
• UNIPDi002-A
• EURACi001-A
• EURACi002-A
• EURACi003-A
• UNIPDi003-A
• UCLi007-A
• CSSi001-A
• CSSi002-A
• CSSi003-A
• CSSi004-A
• CSSi005-A
• PSMi002-A
• PSMi003-A
• EURACi004-A
• CSSi006-A
• PSMi004-A
• IAIi001-A
• PSMi005-A
• PSMi006-A
• PSMi007-A
• PSMi008-A
• PSMi009-A
• IAIi002-A
• IAIi003-A
• IAIi004-A
• IRFMNi002-A
• CIBIOi001-A
• CIBIOi002-A
• IRFMNi002-B
• UNIBSi004-A
• CSSi007-A
• OSRi001-A
• OSRi002-A
• OSRi003-A
• OSRi004-A
• OSRi005-A
• OSRi006-A
• OSRi007-A
• OSRi008-A
• CSSi008-A
• CCMi001-A
• CCMi002-A
• CCMi003-A
• UNIBSi005-A
• UNIBSi005-B
• UNIBSi005-C
• IRFMNi003-A
• EURACi005-A
• UMILi001-A
• UMILi002-A
• UMILi003-A
• UMILi004-A
• UMILi005-A
• UMILi006-A
• UMILi007-A
• UMILi008-A
• UMILi009-A
• UMILi010-A
• UMILi011-A
• FINCBi001-A
• UNIBSi006-A
• UNIBSi006-B
• UNIBSi006-C
• UNIBSi007-A
• UNIBSi007-B
• UNIBSi007-C
• UNIBSi008-A
• UNIBSi008-B
• UNIBSi008-C
• UNIBSi009-A
• UNIBSi009-B
• UNIBSi009-C
• IRFMNi003-A-1
• IRFMNi003-A-2
• CSSi009-A
• CSSi010-A
• CCMi004-A
• UMILi012-A
• UMILi013-A
• UMILi014-A
• UMILi015-A
• UMILi016-A
• UMILi017-A
• UMILi018-A
• UMILi019-A
• UMILi020-A
• UMILi021-A
• UMILi022-A
• UMILi023-A
• UMILi024-A
• UMILi025-A
• UMILi026-A
• UNIBSi010-A
• UNIBSi010-B
• UNIBSi010-C
• SAPi001-A
• SAPi001-A-1
• SAPi002-A
• SAPi003-A
• SAPi004-A
• UNIPDi004-A
• UNIPDi004-B
• IRFMNi003-A-3
• IRFMNi003-A-4
• UNIPDi005-A
• UNIPDi006-A
• CSSi011-A
• UNIBSi011-A
• UNIBSi011-B
• UNIBSi011-C
• UNIBSi012-A
• UNIBSi013-A
• UNIMGi001-A
• UNIMGi002-A
• IRFMNi001-B
• FINCBi002-A
• FINCBi003-A
• UNIPDi007-A
• TIGETi001-A
• TIGETi003-A
• PSMi010-A
• PSMi011-A
• PSMi012-A
• PSMi013-A
• PSMi014-A
• PSMi015-A
• UNIBSi014-A
• UNINAi001-A
• UNINAi002-A
• UNINAi001-B
• UNIMGi003-A
• UNIMGi004-A
• CSSi012-A
• NCUFi001-A
• UNIBSi015-A
• UNIBSi016-A
• UNIBSi016-B
• UNIBSi016-C
• EURACi006-A
• EURACi007-A
• EURACi008-A
• EURACi009-A
• UCSCi001-A
• IRFMNi001-B-1
• CCMi005-A
• OSRi009-A
• OSRi009-A-1
• OSRi010-A
• OSRi010-A-1
• EURACi010-A
• EURACi011-A
• EURACi012-A
• EURACi013-A
• EURACi014-A
• UCSCi002-A
• UNIPVi001-A
• UNIPVi002-A
• UNIPVi003-A
• UNIPVi004-A
• UMILi027-A
• UMILi028-A
• UNIBSi017-A
• CSSi013-A
• CSSi014-A
• CSSi015-A
• CIBIOi003-A
• CIBIOi004-A
• CIBIOi005-A
• CIBIOi006-A
• IRFMNi001-B-2
• IAIi005-A
• IAIi006-A
• IAIi007-A
• IAIi008-A
• IAIi009-A
• CCMi007-A
• CCMi008-A
• CCMi009-A
• CCMi010-A
• CSSi016-A
• IAIi010-A
• CCMi011-A
• FINCBi004-A
• EURACi015-A
• IGGi001-A
• IGGi002-A
• IGGi001-B
• AOUMEYi001-A
• IRFMNMi001-A
• IRFMNi004-A
• IRFMNi005-A
• IRFMNi006-A
• IRFMNi007-A
• IRFMNi008-A
• IGGi003-A
• UNIBSi018-A
• UNIBSi018-B
• UNIBSi019-A
• UNIBSi019-B
• UNIBSi020-A
• UNIBSi020-B
• CSSi017-A
• IGGi004-A
• IGGi005-A
• CIBIOi007-A
• FINCBi005-A
• FINCBi006-A
• UNIMGi005-A
• UNIMGi006-A
• UNIMGi007-A
• UNIMGi008-A
• AOUMEYi002-A
• FSMi001-A
• CCMi012-A
• CSSi018-A
• IGGi006-A
• UMILi029-A
• CSSi019-A
• CSSi020-A
• UNIFEi001-A
• UNIPDi008-A
• UNIPDi008-B
• UNIPDi004-C
• UNIPDi004-D
• UNIPDi009-A
• UNIPDi010-B
• UNIPDi011-A
• UNIMGi009-A
• UNIMGi010-A
• UNIMGi011-A
• UMILi030-A
• UMILi031-A
• ICHi001-A
• ICHi002-A
• ICHi003-A
• ICHi004-A