Italy

Legal status	VERY RESTRICTIVE
Key organization	Ministry of Health (Italian) National Bioethics Committee
Policy	hESC research is prohibited unless it is specifically aimed at improving the therapeutic and medical condition of the embryo concerned. Derivation of embryonic stem cell lines is prohibited. Embryonic cell import is allowed for research.
Legislation	Regulation of Medically Assisted Reproduction, Law No. 40, Article 13 (2004)
Legislation Link	http://www.ieb-eib.org/nl/pdf/loi-pma-italie-english.pdf
Embryonic stem cell research policy	The opinion of a local ethics committee is required prior to the import of hES cell lines.
Research with embryo	Any experimentation on human embryos is expressly prohibits by Law 40/2004.
Somatic cell nuclear transfer	Forbidden.
Genetic modification or selection	Forbidden.
Privacy and data protection	Italian Personal Data Protection Code, Legislative Decree No. 196 of June 30, 2003: http://www.garanteprivacy.it/gar ante/doc.jsp?ID=1030925

Projects

• A functional dissection of the genetic circuits selected in Anatomically Modern Humans and inferred from the study of neurodevelopmental disorders
• Designer extracellular matrices to program healthy and diseased cardiac morphogenesis
• Dissecting the regulatory logic of cell fate reprogramming through integrative and single cell genomics
• HD-DittoGraph: a digital human Embryonic Stem Cell platform for Huntington’s repeats
• Patient-derived disease modeling as a tool to uncover the molecular pathogenesis of neurodevelopmental disorders (NDDs)
• Unraveling huntingtin function in cortical and striatal human development

Provider

• Centro Cardiologico Monzino IRCCS
• EURAC Research Institute for Biomedicine
• Fondazione Casa Sollievo della Sofferenza IRCCS
• Fondazione IRCCS Istituto Neurologico C. Besta
• International Centre for Genetic Engineering and Biotechnology
• IRCCS - Istituto di Ricerche Farmacologiche Mario Negri
• IRCCS Policlinico San Matteo
• Istituto Auxologico Italiano IRCCS
• Ospedale San Raffaele
• Università degli Studi di Trento
• University of Brescia
• University of Milan
• University of Padova
• University of Trieste

hESC Cell lines

• (none)

hiPSC Cell lines

• IRFMNi001-A
• UCLi007-A
• CSSi001-A
• CSSi002-A
• CSSi003-A
• CSSi004-A
• CSSi005-A
• CSSi006-A
• IAIi001-A
• IAIi002-A
• IAIi003-A
• IAIi004-A
• IRFMNi002-A
• CSSi007-A
• OSRi004-A
• OSRi005-A
• CSSi008-A
• UMILi001-A
• UMILi002-A
• UMILi003-A
• UMILi004-A
• UMILi005-A
• UMILi006-A
• UMILi007-A
• UMILi008-A
• UMILi010-A
• UMILi011-A